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Cleopatra Selene I
Koine Greek: Κλεοπάτρα Σελήνη
Romanized: Kleopatra Selene
Latin: Cleopatra Luna
Dynasty Ptolemaic Dynasty
Pharaoh(s) Ptolemy VIIIPtolemy XII
Titles King's Great Wife
King's Daughter
Father Ptolemy VIII
Mother Cleopatra III
Spouse(s) Ptolemy IX, Ptolemy X
Issue Ptolemy XI
Born c. 135–130 BC
Died 69 BC, Seleucia (aged 61-66)
Burial Unknown
Not to be confused with Cleopatra Selene II.
For other pages by this name, see Cleopatra.

Cleopatra Selene I (Koine Greek: Κλεοπάτρα Σελήνη) was a queen consort to Ptolemy IX Lathyros of the Ptolemaic Dynasty during the Hellenistic Period.

She was the daughter of Ptolemy VIII and Cleopatra III. She was married to Lathyros after her sister Cleopatra IV was pushed out by her mother. She was not made co-ruler, unlike the many sister-wives of Ptolemaic kings. She bore Lathyros Berenice III.

She may have also wed Ptolemy X Alexander I later, possibly bearing him Ptolemy XI Alexander II.